Magnesium deficiency is associated with a high frequency of cardiac arrhythmia, hypertension and sudden ischemic death. We investigated the if vivo effects of intravenous magnesium administration in a rat model of chemically induced (FeCl3) carotid thrombosis. The infusion of magnesium sulfate (MgSO4) before the topical application of FeCl5 prevented thrombus formation at concentrations of 0.3 M and 0.6 M, and delayed it even at 0.15 M. Similar results were obtained with MgCl2. The infusion of MgSO4 0.6 M seven minutes after FeCl3 application delayed but did not prevent thrombus formation. MgSO4 slightly reduced platelet aggregation ex vivo without affecting plasma clotting tests, but in vivo blood clotting time was markedly prolonged (tail transection method), thus indicating profoundly impaired coagulation. These data provide a rationale for the use of magnesium as an antithrombotic agent. but its pharmacological effect critically depends on the timing of administration.

Magnesium inhibits arterial thrombi after vascular injury in rat: in vivo impairment of coagulation / L. Mussoni, L. Sironi, L. Tedeschi, A.M. Calvio, S. Colli, E. Tremoli. - In: THROMBOSIS AND HAEMOSTASIS. - ISSN 0340-6245. - 86:5(2001 Nov), pp. 1292-1295.

Magnesium inhibits arterial thrombi after vascular injury in rat: in vivo impairment of coagulation

L. Mussoni
Primo
;
L. Sironi
Secondo
;
S. Colli
Penultimo
;
E. Tremoli
Ultimo
2001-11

Abstract

Magnesium deficiency is associated with a high frequency of cardiac arrhythmia, hypertension and sudden ischemic death. We investigated the if vivo effects of intravenous magnesium administration in a rat model of chemically induced (FeCl3) carotid thrombosis. The infusion of magnesium sulfate (MgSO4) before the topical application of FeCl5 prevented thrombus formation at concentrations of 0.3 M and 0.6 M, and delayed it even at 0.15 M. Similar results were obtained with MgCl2. The infusion of MgSO4 0.6 M seven minutes after FeCl3 application delayed but did not prevent thrombus formation. MgSO4 slightly reduced platelet aggregation ex vivo without affecting plasma clotting tests, but in vivo blood clotting time was markedly prolonged (tail transection method), thus indicating profoundly impaired coagulation. These data provide a rationale for the use of magnesium as an antithrombotic agent. but its pharmacological effect critically depends on the timing of administration.
Animals; Ferric Compounds; Blood Coagulation Tests; Dose-Response Relationship, Drug; Magnesium Sulfate; Chlorides; Disease Models, Animal; Thrombosis; Carotid Arteries; Rats; Platelet Aggregation; Rats, Sprague-Dawley; Hemostasis; Time Factors; Male
Settore BIO/14 - Farmacologia
http://www.schattauer.de/en/magazine/subject-areas/journals-a-z/thrombosis-and-haemostasis/contents/archive/issue/876/manuscript/2965/show.html
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/194011
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