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The model of promyelocytic leukemia cells HL60 was utilized to study the accumulation of 5-lipoxygenase mRNA during the cellular differentiation induced by DMSO. In the present study a strict correlation between the increase in state of differentiation of HL60 and accumulation of 5-lipoxygenase mRNA is demonstrated, indicating that HL60 cells are an interesting model for the study of drugs which could interfere with the synthesis of the enzyme.

5-Lipoxygenase gene expression in HL60 cells during differentiation with DMSO / G. Piechele, S. Colli, E. Tremoli, A. Maggi. - In: PHARMACOLOGICAL RESEARCH. - ISSN 1043-6618. - 27:1(1993), pp. 53-60.

5-Lipoxygenase gene expression in HL60 cells during differentiation with DMSO

S. Colli
Secondo
;E. Tremoli
Penultimo
;A. Maggi
Ultimo
1993

Abstract

The model of promyelocytic leukemia cells HL60 was utilized to study the accumulation of 5-lipoxygenase mRNA during the cellular differentiation induced by DMSO. In the present study a strict correlation between the increase in state of differentiation of HL60 and accumulation of 5-lipoxygenase mRNA is demonstrated, indicating that HL60 cells are an interesting model for the study of drugs which could interfere with the synthesis of the enzyme.
English
RNA, Messenger; Dimethyl Sulfoxide; Gene Expression Regulation, Enzymologic; Tumor Cells, Cultured; Neutrophils; Humans; Arachidonate 5-Lipoxygenase; Leukemia, Promyelocytic, Acute; Cell Differentiation
Settore BIO/11 - Biologia Molecolare
Articolo
Esperti anonimi
1993
PHARMACOLOGICAL RESEARCH
27
1
53
60
Pubblicato
Periodico con rilevanza internazionale
Pubmed
WOS:A1993KM28100005
2-s2.0-0027417115
8456058
info:eu-repo/semantics/article
5-Lipoxygenase gene expression in HL60 cells during differentiation with DMSO / G. Piechele, S. Colli, E. Tremoli, A. Maggi. - In: PHARMACOLOGICAL RESEARCH. - ISSN 1043-6618. - 27:1(1993), pp. 53-60.
none
Prodotti della ricerca::01 - Articolo su periodico
4
262
Article (author)
no
G. Piechele, S. Colli, E. Tremoli, A. Maggi
01 - Articolo su periodico
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/193862
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