An efficient synthesis of a beta-lactam precursor of the serine protease, prostate-specific antigen inhibitor 1 has been accomplished. The synthesis relies on two completely stercoselective reactions that allow the introduction of the stereocenters at C-3 and C-4 of the azetidinone ring in a predictable manner. (C) 2002 Elsevier Science Ltd. All rights reserved.
Efficient and highly stereoselective synthesis of a beta-lactam inhibitor of the serine protease prostate-specific antigen / R. Annunziata, M. Benaglia, M. Cinquini, F. Cozzi, A. Puglisi. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - 10:6(2002), pp. 1813-1818.
Efficient and highly stereoselective synthesis of a beta-lactam inhibitor of the serine protease prostate-specific antigen
R. AnnunziataPrimo
;M. BenagliaSecondo
;M. Cinquini;F. CozziPenultimo
;A. PuglisiUltimo
2002
Abstract
An efficient synthesis of a beta-lactam precursor of the serine protease, prostate-specific antigen inhibitor 1 has been accomplished. The synthesis relies on two completely stercoselective reactions that allow the introduction of the stereocenters at C-3 and C-4 of the azetidinone ring in a predictable manner. (C) 2002 Elsevier Science Ltd. All rights reserved.
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