We report a case of Philadelphia chromosome (Ph) positive thrombocythemia with a complex translocation. G-banding analysis showed the predominant karyotype to be 46,XX,t(9;15;22). Southern blot analysis revealed a rearrangement within the breakpoint cluster region on chromosome 22 similar to findings in chronic myeloid leukemia. These data suggest the presence of a complex Ph translocation involving t(9;15;22)(q34.1 or q34.3;q26.1;q11 or q13).
Philadelphia-positive thrombocythemia with a complex translocation involving chromosomes 9, 15, and 22 / A. P. Palumbo, M. Boccadoro, S. Battaglio, P. Corradini, B. Giovinazzo, G. Avanzi, G. Ponzio. - In: CANCER GENETICS AND CYTOGENETICS. - ISSN 0165-4608. - 39:1(1989 May), pp. 77-80-80.
Philadelphia-positive thrombocythemia with a complex translocation involving chromosomes 9, 15, and 22
P. Corradini;
1989-05
Abstract
We report a case of Philadelphia chromosome (Ph) positive thrombocythemia with a complex translocation. G-banding analysis showed the predominant karyotype to be 46,XX,t(9;15;22). Southern blot analysis revealed a rearrangement within the breakpoint cluster region on chromosome 22 similar to findings in chronic myeloid leukemia. These data suggest the presence of a complex Ph translocation involving t(9;15;22)(q34.1 or q34.3;q26.1;q11 or q13).
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