A multi-centre uncontrolled clinical trial was performed in 42 Italian hospitals to evaluate the efficacy and tolerance of an instant suspension of naproxen, a well known anti-inflammatory drug. A total of 390 adults of all ages with musculoskeletal rheumatic diseases or minor traumatic injuries entered the trial. Patients received 500 mg naproxen instant suspension twice daily after meals, for 1-4 weeks. Assessment of signs and symptoms was made before starting the therapy, after 3 days and at the end of the treatment period. The drug produced a rapid and progressive relief of pain and articular symptoms in most patients and was equally effective in all the diagnostic sub-groups. The efficacy of treatment was 'excellent' or 'good' in about 85% of patients, 'moderate' in 10% and 'minimal' or 'absent' in about 5%. Almost 90% of patients had no side-effects; 5% were withdrawn because of unwanted effects. No correlation between incidence or intensity of side-effects and age of the patients or duration of therapy was observed. The complaints reported are common to other anti-rheumatic drugs, e.g. epigastric pain, pyrosis, nausea, vomiting and headache. In conclusion, naproxen instant suspension is highly effective and well tolerated.
Efficacy and tolerance of naproxen instant suspension formulation: a post-marketing survey / C. I. Cordaro, A. Sartini, F. Celotti. - In: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH. - ISSN 0300-0605. - 16:2(1988), pp. 157-165.
|Titolo:||Efficacy and tolerance of naproxen instant suspension formulation: a post-marketing survey|
CELOTTI, FABIO MARIA (Ultimo)
|Parole Chiave:||Naproxen; Humans; Clinical Trials as Topic; Wounds and Injuries; Aged; Rheumatic Diseases; Aged, 80 and over; Suspensions; Adult; Middle Aged; Adolescent; Female; Male|
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
|Data di pubblicazione:||1988|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1177/030006058801600211|
|Appare nelle tipologie:||01 - Articolo su periodico|