We investigated whether dopamine influences the rate of adaptation to a visuomotor distortion and the transfer of this learning from the right to the left limb in human subjects. We thus studied patients with Parkinson disease as a putative in vivo model of dopaminergic denervation. Despite normal adaptation rates, patients showed a reduced transfer compared with age-matched healthy controls. The magnitude of the transfer, but not of the adaptation rate, was positively predicted by the values of dopamine-transporter binding of the right caudate and putamen. We conclude that striatal dopaminergic activity plays an important role in the transfer of visuomotor skills.

Dopaminergic striatal innervation predicts interlimb transfer of a visuomotor skill / I.U. Isaias, C. Moisello, G. Marotta, M. Schiavella, M. Canesi, B. Perfetti, P. Cavallari, G. Pezzoli, M.F. Ghilardi. - In: THE JOURNAL OF NEUROSCIENCE. - ISSN 0270-6474. - 31:41(2011 Oct 12), pp. 14458-14462.

Dopaminergic striatal innervation predicts interlimb transfer of a visuomotor skill

I.U. Isaias
Primo
;
P. Cavallari;
2011

Abstract

We investigated whether dopamine influences the rate of adaptation to a visuomotor distortion and the transfer of this learning from the right to the left limb in human subjects. We thus studied patients with Parkinson disease as a putative in vivo model of dopaminergic denervation. Despite normal adaptation rates, patients showed a reduced transfer compared with age-matched healthy controls. The magnitude of the transfer, but not of the adaptation rate, was positively predicted by the values of dopamine-transporter binding of the right caudate and putamen. We conclude that striatal dopaminergic activity plays an important role in the transfer of visuomotor skills.
Parkinsons-disease; synaptic plasticity; basal ganglia; adaptation; consolidation; binding; lesions; system; tremor; brain
Settore BIO/09 - Fisiologia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/193414
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