We investigated whether dopamine influences the rate of adaptation to a visuomotor distortion and the transfer of this learning from the right to the left limb in human subjects. We thus studied patients with Parkinson disease as a putative in vivo model of dopaminergic denervation. Despite normal adaptation rates, patients showed a reduced transfer compared with age-matched healthy controls. The magnitude of the transfer, but not of the adaptation rate, was positively predicted by the values of dopamine-transporter binding of the right caudate and putamen. We conclude that striatal dopaminergic activity plays an important role in the transfer of visuomotor skills.
|Titolo:||Dopaminergic striatal innervation predicts interlimb transfer of a visuomotor skill|
ISAIAS, IOANNIS UGO (Primo)
|Parole Chiave:||Parkinsons-disease; synaptic plasticity; basal ganglia; adaptation; consolidation; binding; lesions; system; tremor; brain|
|Settore Scientifico Disciplinare:||Settore BIO/09 - Fisiologia|
|Data di pubblicazione:||12-ott-2011|
|Digital Object Identifier (DOI):||10.1523/JNEUROSCI.3583-11.2011|
|Appare nelle tipologie:||01 - Articolo su periodico|