Inflammation is a key feature of HIV infection and is correlated with long-term negative cardiovascular outcomes. Therapy-induced increases in CD4(+) cell counts can control inflammation, as shown by decreases of coagulation and inflammation markers during efficacious therapy. Maraviroc, a CCR5-antagonist, has resulted in larger increases in CD4(+) counts both in naïve and experienced subjects compared to traditional antiretroviral therapy
Levels of soluble endothelial protein C receptor are associated with CD4(+) changes in Maraviroc-treated HIV-infected patients / S. Nozza, M. Pogliaghi, S. Chiappetta, V. Spagnuolo, G. Fontana, C. Razzari, G. Tambussi, E.M. Faioni. - In: PLOS ONE. - ISSN 1932-6203. - 7:6(2012), pp. e37032.e37032-e37032.e37037.
Levels of soluble endothelial protein C receptor are associated with CD4(+) changes in Maraviroc-treated HIV-infected patients
G. Fontana;E.M. FaioniUltimo
2012
Abstract
Inflammation is a key feature of HIV infection and is correlated with long-term negative cardiovascular outcomes. Therapy-induced increases in CD4(+) cell counts can control inflammation, as shown by decreases of coagulation and inflammation markers during efficacious therapy. Maraviroc, a CCR5-antagonist, has resulted in larger increases in CD4(+) counts both in naïve and experienced subjects compared to traditional antiretroviral therapy
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