5-hydroxytryptamine (5HT) treatment produced dose-related contractions in the human internal mammary artery with an EC50 value of 3.4 X 10(-7) M. The 5HT2 receptor antagonist ketanserin reversed the contractions evoked by 5HT in a competitive manner at a low concentration (10(-8) M), whereas a noncompetitive antagonism was apparent at higher concentrations (5 X 10(-8) M to 5 X 10(-7) M). The alpha 1-blocking component of ketanserin was evaluated by studying the effect of ketanserin upon the contractile response evoked by norepinephrine. Up to 10(-7) M, ketanserin did not influence norepinephrine-induced contractions. These findings indicate that the mammary artery is a vascular tissue sensitive to contractions induced by 5HT and that the drug ketanserin antagonizes this contractile response through the 5HT2 receptor subtype.

5-Hydroxytryptamine induces contraction in isolated human mammary artery: effect of ketanserin / A. Monopoli, A. Conti, A. Forlani, E. Ongini, C. Antona, P. Biglioli. - In: CARDIOVASCULAR DRUGS AND THERAPY. - ISSN 0920-3206. - 4 Suppl 1:1(1990 Jan), pp. 59-61-61.

5-Hydroxytryptamine induces contraction in isolated human mammary artery: effect of ketanserin

C. Antona;P. Biglioli
1990-01

Abstract

5-hydroxytryptamine (5HT) treatment produced dose-related contractions in the human internal mammary artery with an EC50 value of 3.4 X 10(-7) M. The 5HT2 receptor antagonist ketanserin reversed the contractions evoked by 5HT in a competitive manner at a low concentration (10(-8) M), whereas a noncompetitive antagonism was apparent at higher concentrations (5 X 10(-8) M to 5 X 10(-7) M). The alpha 1-blocking component of ketanserin was evaluated by studying the effect of ketanserin upon the contractile response evoked by norepinephrine. Up to 10(-7) M, ketanserin did not influence norepinephrine-induced contractions. These findings indicate that the mammary artery is a vascular tissue sensitive to contractions induced by 5HT and that the drug ketanserin antagonizes this contractile response through the 5HT2 receptor subtype.
Serotonin Antagonists; Muscle, Smooth, Vascular; Humans; Norepinephrine; Ketanserin; Muscle Contraction; Serotonin; Female; Mammary Arteries
Settore MED/23 - Chirurgia Cardiaca
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/193121
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