5-hydroxytryptamine (5HT) treatment produced dose-related contractions in the human internal mammary artery with an EC50 value of 3.4 X 10(-7) M. The 5HT2 receptor antagonist ketanserin reversed the contractions evoked by 5HT in a competitive manner at a low concentration (10(-8) M), whereas a noncompetitive antagonism was apparent at higher concentrations (5 X 10(-8) M to 5 X 10(-7) M). The alpha 1-blocking component of ketanserin was evaluated by studying the effect of ketanserin upon the contractile response evoked by norepinephrine. Up to 10(-7) M, ketanserin did not influence norepinephrine-induced contractions. These findings indicate that the mammary artery is a vascular tissue sensitive to contractions induced by 5HT and that the drug ketanserin antagonizes this contractile response through the 5HT2 receptor subtype.
|Titolo:||5-Hydroxytryptamine induces contraction in isolated human mammary artery: effect of ketanserin|
|Parole Chiave:||Serotonin Antagonists; Muscle, Smooth, Vascular; Humans; Norepinephrine; Ketanserin; Muscle Contraction; Serotonin; Female; Mammary Arteries|
|Settore Scientifico Disciplinare:||Settore MED/23 - Chirurgia Cardiaca|
|Data di pubblicazione:||gen-1990|
|Digital Object Identifier (DOI):||10.1007/BF00053428|
|Appare nelle tipologie:||01 - Articolo su periodico|