Disclosed are linear or branched poly(amidoamine)s contg. guanidine groups useful as transfection agents, as scaffolds for tissue engineering, and in general applications as biomaterials. The crosslinked poly(amidoamine) structures can swell in aq. media, thus giving rise to hydrogels. Thus, to a mixt. of 2,2-Bis(acrylamido)acetic acid and 4-aminobutylguanidine sulfate in water, LiOH is added and the mixt. is stirred until it becomes clear soln. After 72 h at room temp. the mixt. is acidified with HCl, filtered or dialyzed, and then lyophilized to give a white powder sol. in water.
Poli(amido-ammine) lineari o reticolate contenenti gruppi laterali guanidinici / R. Cavalli, F. Chiellini, P. Ferruti, E. Ranucci.
Poli(amido-ammine) lineari o reticolate contenenti gruppi laterali guanidinici
P. FerrutiPenultimo
;E. RanucciUltimo
2009
Abstract
Disclosed are linear or branched poly(amidoamine)s contg. guanidine groups useful as transfection agents, as scaffolds for tissue engineering, and in general applications as biomaterials. The crosslinked poly(amidoamine) structures can swell in aq. media, thus giving rise to hydrogels. Thus, to a mixt. of 2,2-Bis(acrylamido)acetic acid and 4-aminobutylguanidine sulfate in water, LiOH is added and the mixt. is stirred until it becomes clear soln. After 72 h at room temp. the mixt. is acidified with HCl, filtered or dialyzed, and then lyophilized to give a white powder sol. in water.
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