Polycarbonates -[OCO2R1OCO2R2]-a [a = 2-300; R1, R2 = aliph. alicyclic C2-18, polyoxyalkylene residue of -[CHR3(CH2)nO]m-CHR3(CH2)n- (I) (R3 = H, Me; n = 1-3, m = 1-200, or a polyester residue of -[R4CO2]x-[R5CO2]y-R6 (x, y = 1-50; R4, R5 = aliph. C1-4 hydrocarbyl; R6 = aliph. or alicyclic C2-18, polyoxyalkylene residue of I]. are used as bioerosible pharmaceutical matrixes for slow release of the active ingredients. Thus, 1,1'-carbonyldiimidazole was reacted with PEG to obtain diimidazolyl formate which was mixed with 1,6-hexanediol and heated at 60° to obtain a polycarbonate liq.
Polycarbonates and their use for preparation of bioerosible pharmaceutical matrices / P. Ferruti, E. Ranucci, F. Bignotti.
Polycarbonates and their use for preparation of bioerosible pharmaceutical matrices
E. RanucciSecondo
;
1992
Abstract
Polycarbonates -[OCO2R1OCO2R2]-a [a = 2-300; R1, R2 = aliph. alicyclic C2-18, polyoxyalkylene residue of -[CHR3(CH2)nO]m-CHR3(CH2)n- (I) (R3 = H, Me; n = 1-3, m = 1-200, or a polyester residue of -[R4CO2]x-[R5CO2]y-R6 (x, y = 1-50; R4, R5 = aliph. C1-4 hydrocarbyl; R6 = aliph. or alicyclic C2-18, polyoxyalkylene residue of I]. are used as bioerosible pharmaceutical matrixes for slow release of the active ingredients. Thus, 1,1'-carbonyldiimidazole was reacted with PEG to obtain diimidazolyl formate which was mixed with 1,6-hexanediol and heated at 60° to obtain a polycarbonate liq.
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