17α-Alkylated androgens are highly effective in preventing attacks in HAE patients. These drugs, however, seem to be implicated in the development of cholestatic jaundice, peliosis hepatis, and liver tumors. In order to assess the risk-benefit balance of the long-term therapy with androgen derivatives, a follow-up investigation was performed in 13 HAE patients. The results of this study indicate that long-term treatment (15 to 47 mo) with low doses of danazol or stanozolol does not induce significant hepatic damage detectable by laboratory tests or liver biopsy. However, the limited number of patients, although in a rather long period of observation, still suggests a careful control and the use of minimal effective doses.
Morphologic evaluation of the liver in hereditary angioedema patients on long-term treatment with androgen derivatives / M. CIcardi, L. Bergamaschini, A. Tucci, A. Agostoni, G. Tornaghi, G. Coggi, R. Colombi , G. Viale. - In: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. - ISSN 0091-6749. - 72:3(1983), pp. 294-298.
|Titolo:||Morphologic evaluation of the liver in hereditary angioedema patients on long-term treatment with androgen derivatives|
|Settore Scientifico Disciplinare:||Settore MED/09 - Medicina Interna|
|Data di pubblicazione:||1983|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/0091-6749(83)90034-9|
|Appare nelle tipologie:||01 - Articolo su periodico|