The complex [PPN][Rh(CO)(4)] is a very efficient catalyst for the conversion of 2-nitrostilbene to 2-phenylindole by reduction by CO followed by cyclisation. The reaction is quite selective (up to 85%) and the only observable by-product is the amine corresponding to the starting material. The addition of 2-hydroxypyridine increases both conversion and selectivity. but simple pyridine deactivates the catalytic system. The reaction conditions have been optimised.
Transition metal-mediated N-heterocyclisation reactions. Synthesis of 2-phenylindole by reduction by CO of 2-nitrostilbene catalysed by [Rh(CO)(4)](-) / F. Ragaini, S. Tollari, S. Cenini, E. Bettetini. - In: JOURNAL OF MOLECULAR CATALYSIS. A: CHEMICAL. - ISSN 1381-1169. - 111:1-2(1996), pp. 91-96. [10.1016/1381-1169(96)00209-9]
Transition metal-mediated N-heterocyclisation reactions. Synthesis of 2-phenylindole by reduction by CO of 2-nitrostilbene catalysed by [Rh(CO)(4)](-)
F. RagainiPrimo
;S. TollariSecondo
;S. CeniniPenultimo
;
1996
Abstract
The complex [PPN][Rh(CO)(4)] is a very efficient catalyst for the conversion of 2-nitrostilbene to 2-phenylindole by reduction by CO followed by cyclisation. The reaction is quite selective (up to 85%) and the only observable by-product is the amine corresponding to the starting material. The addition of 2-hydroxypyridine increases both conversion and selectivity. but simple pyridine deactivates the catalytic system. The reaction conditions have been optimised.
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