Sixteen patients underwent evaluation of duodenogastric reflux and gastric function 1 to 7 years after esophagectomy, high intrathoracic anastomosis, and pyloric divulsion for esophageal cancer. Ten patients (62%) had either postoperative digestive symptoms or endoscopic mucosal lesions, cholescintigraphy demonstrated duodenogastric reflux in 11 cases (69%). No gastric motor activity was recorded on manometry. 24-hour pH gastric monitoring showed that the area under the curve less than 4 was significantly less than in controls (p = 0.0003). The results of the present study show that duodenogastric reflux is a common event after esophageal replacement with the stomach. The interaction between acid and alkaline secretions plays a role in the pathogenesis of mucosal lesions, and it may explain the partial failure of the current therapeutic strategies.
|Titolo:||[Functional evaluation of the intrathoracic stomach after esophagectomy for esophageal cancer]|
BONAVINA, LUIGI (Primo)
|Parole Chiave:||Gastric Emptying; Duodenogastric Reflux; Hydrogen-Ion Concentration; Humans; Esophageal Neoplasms; Aged; Middle Aged; Manometry; Follow-Up Studies; Stomach; Male; Female|
|Settore Scientifico Disciplinare:||Settore MED/18 - Chirurgia Generale|
|Data di pubblicazione:||15-apr-1991|
|Appare nelle tipologie:||01 - Articolo su periodico|