Intima-media thickness (IMT) of the carotid artery is considered a marker of carotid/coronary atherosclerosis and it is widely used in pharmacological and clinical studies to follow the natural, pathological or pharmacological induced changes of arterial walls. previous studies have been performed by measuring IMT with highly sophisticated techniques usually not available in the normal clinical practice where, instead, a simple electronic caliper is generally used. Aim of the present observational study was to evaluate whether data obtained by measuring the IMT with an electronic caliper can be considered as representative of those obtained by using more sophisticated methods for IMT measurement. Ultrasonographical and clinical data relative to 963 patients attending the Lipid Clinic of the Enrica Grossi Paoletti Center in Milan have been analysed. Specifically, it has been evaluated whether IMT discriminates between patients with and without major vascular events and its association with the presence and number of major atherosclerosis risk factors. Maximal- and Mean-Maximal IMT were assessed by B-Mode ultrasonography and measured with an electronic caliper. Also by using this simple method of measurement, IMT values of the carotid artery were significantly greater in men than in women and were directly related to age, SBP, TC, LDL-C, TG, blood glucose and uric acid and inversely with HDL-C. Among risk factors, IMT was one of the best discriminants between patients with and without major vascular events. The IMT was also linearly related to the number of vascular risk factors, either in the whole group, or after stratification into age classes. These observations establish the predictive validity of IMT measured with the electronic caliper in large scale epidemiological studies and for the screening of individuals at high risk.
Carotid artery IMT measured with an electronic caliper in patients attending a lipid clinic / D. Baldassarre, M. Amato, E. Tremoli, C.R. Sirtori. - In: ATHEROSCLEROSIS. - ISSN 0021-9150. - 135:1(1997 Dec), pp. S6-S6. ((Intervento presentato al 11. convegno Congresso Nazionale della Società Italiana per lo Studio dell’Arteriosclerosi tenutosi a Vibo Valentia, Italia nel 1997.
|Titolo:||Carotid artery IMT measured with an electronic caliper in patients attending a lipid clinic|
BALDASSARRE, DAMIANO (Primo)
TREMOLI, ELENA (Penultimo)
SIRTORI, CESARE (Ultimo)
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||dic-1997|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/S0021-9150(97)89967-4|
|Appare nelle tipologie:||01 - Articolo su periodico|