In HIV-infected adults prolonged monotherapy with zidovudine may be associated with the appearance of HIV strains with decreased zidovudine sensitivity, owing to specific mutations in the reverse transcriptase (RT) gene, and this has been suggested to be a reason for reduced zidovudine efficacy. This study was undertaken to determine the appearance of mutation at codon 215 of the RT gene in proviral DNA from PBMCs in HIV-infected children.
HIV-1 reverse transcriptase codon 215 mutation and clinical outcome in children treated with zidovudine / N. Principi, P. Marchisio, M. P. De Pasquale, E. Massironi, R. Tornaghi, T. Vago. - In: AIDS RESEARCH AND HUMAN RETROVIRUSES. - ISSN 0889-2229. - 10:6(1994 Jun), pp. 721-726.
HIV-1 reverse transcriptase codon 215 mutation and clinical outcome in children treated with zidovudine
N. PrincipiPrimo
;P. MarchisioSecondo
;
1994
Abstract
In HIV-infected adults prolonged monotherapy with zidovudine may be associated with the appearance of HIV strains with decreased zidovudine sensitivity, owing to specific mutations in the reverse transcriptase (RT) gene, and this has been suggested to be a reason for reduced zidovudine efficacy. This study was undertaken to determine the appearance of mutation at codon 215 of the RT gene in proviral DNA from PBMCs in HIV-infected children.
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