The effects of hyperinsulinemia on local cerebral glucose utilization were studied by the quantitative autoradiographic 2-[14C]deoxyglucose method in normal conscious rats under steady-state normoglycemic conditions. Hyperinsulinemia and a steady state of normoglycemia were achieved and maintained during the experimental period by a continuous intravenous (i.v.) infusion of insulin given simultaneously with a programmed i.v. infusion of D-glucose. Hyperinsulinemia under normoglycemic conditions did not change the average rate of glucose utilization in the brain as a whole, but significant increases in local glucose utilization were found selectively in the ventromedial, dorsomedial, and anterior hypothalamic nuclei. The results suggest that a known anatomical pathway linking the dorsomedial and anterior nuclei with the ventromedial nucleus of the hypothalamus may be physiologically activated in response to hyperinsulinemia.

Effects of insulin on local cerebral glucose utilization in the rat / G. Lucignani, H. Namba, A. Nehlig, L. J. Porrino, C. Kennedy, L. Sokoloff. - In: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. - ISSN 0271-678X. - 7:3(1987 Jun), pp. 309-14-314.

Effects of insulin on local cerebral glucose utilization in the rat

G. Lucignani;
1987-06

Abstract

The effects of hyperinsulinemia on local cerebral glucose utilization were studied by the quantitative autoradiographic 2-[14C]deoxyglucose method in normal conscious rats under steady-state normoglycemic conditions. Hyperinsulinemia and a steady state of normoglycemia were achieved and maintained during the experimental period by a continuous intravenous (i.v.) infusion of insulin given simultaneously with a programmed i.v. infusion of D-glucose. Hyperinsulinemia under normoglycemic conditions did not change the average rate of glucose utilization in the brain as a whole, but significant increases in local glucose utilization were found selectively in the ventromedial, dorsomedial, and anterior hypothalamic nuclei. The results suggest that a known anatomical pathway linking the dorsomedial and anterior nuclei with the ventromedial nucleus of the hypothalamus may be physiologically activated in response to hyperinsulinemia.
Rats, Inbred Strains; Rats; Animals; Hypothalamus; Glucose; Brain; Hemodynamics; Deoxyglucose; Autoradiography; Male; Insulin; Blood Glucose
Settore MED/36 - Diagnostica per Immagini e Radioterapia
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/191956
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