Several second-generation protease inhibitors have been developed over the last few years. These compounds have been used in preregistrative clinical trials or are currently in various Phases (I, II or III) of their progress towards use in HIV-1-infected patients. All drugs in this category have been designed in order to reach high plasma levels and possibly overcome the issue of cross-resistance among the compounds belonging to this class. Taking into account the rapid occurrence of protease inhibitor cross-resistance, clinicians who are treating patients living with HIV/AIDS will need new active protease inhibitors in the near future. These newly developed compounds will be the subject of our review.

New HIV protease inhibitors for drug-resistant viruses / S. Rusconi, O. Viganò. - In: THERAPY. - ISSN 1475-0708. - 3:1(2006), pp. 79-88. [10.2217/14750708.3.1.79]

New HIV protease inhibitors for drug-resistant viruses

S. Rusconi
Primo
;
O. Viganò
Ultimo
2006

Abstract

Several second-generation protease inhibitors have been developed over the last few years. These compounds have been used in preregistrative clinical trials or are currently in various Phases (I, II or III) of their progress towards use in HIV-1-infected patients. All drugs in this category have been designed in order to reach high plasma levels and possibly overcome the issue of cross-resistance among the compounds belonging to this class. Taking into account the rapid occurrence of protease inhibitor cross-resistance, clinicians who are treating patients living with HIV/AIDS will need new active protease inhibitors in the near future. These newly developed compounds will be the subject of our review.
Clinical efficacy; Drug-resistance; HIV-1; Novel compounds; Protease inhibitors; Response
Settore MED/17 - Malattie Infettive
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/191924
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