Since functional properties in the vasculature of hypercholesterolemic subjects are impaired, a six-month pravastatin treatment (20 mg/die) was tested in an open design, on the impaired unstimulated forearm arterial compliance (Un-FAC(AUC)) of 14 asymptomatic type IIa familial hypercholesterolemic patients. In order to evaluate whether FAC(AUC) changes might be related to the extent of cholesterol reduction achieved, this evaluation was carried out in five severely hypercholesterolemic patients, undergoing LDL-apheresis.

Effect of plasma cholesterol reduction by pravastatin on the functional properties of forearm arteries in hypercholesterolemic patients / D. Baldassarre, G. Busnach, M. Amato, F. Pazzucconi, C. R. Sirtori. - In: NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES. - ISSN 0939-4753. - 9:3(1999 Jun), pp. 108-117.

Effect of plasma cholesterol reduction by pravastatin on the functional properties of forearm arteries in hypercholesterolemic patients

D. Baldassarre;F. Pazzucconi;C. R. Sirtori
1999-06

Abstract

Since functional properties in the vasculature of hypercholesterolemic subjects are impaired, a six-month pravastatin treatment (20 mg/die) was tested in an open design, on the impaired unstimulated forearm arterial compliance (Un-FAC(AUC)) of 14 asymptomatic type IIa familial hypercholesterolemic patients. In order to evaluate whether FAC(AUC) changes might be related to the extent of cholesterol reduction achieved, this evaluation was carried out in five severely hypercholesterolemic patients, undergoing LDL-apheresis.
Arterial compliance; Hypercholesterolemia; LDL-apheresis; Plethysmography; Pravastatin
Settore BIO/14 - Farmacologia
NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/191702
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