The plasma levels of three lysosomal enzymes, β-D-N-acetylglucosaminidase, β-D-glucuronidase, and α-L-fucosidase, were fluorimetrically determined in seven insulin-dependent diabetic patients one day before, one day after, and during a two-day treatment with the artificial pancreas, at 4 to 5 h intervals. A statistically significant decrease of the plasma level of each enzymes was observed during artificial pancreas treatment. The extent of decrease was 30 to 35% for β-N-acetylglucosaminidase, 35 to 40% for β-D-glucuronidase, and 20 to 25% for α-L-fucosidase. The decrease occurred earlier (at the first day of treatment) for β-D-N-acetylglucosaminidase, and later (at the second day of treatment, and lasting to the first day after treatment) for the other two enzymes. These results suggest a direct connection between the lysosomal apparatus and insulin-controlled metabolic pathways, and a potential role for lysosomal enzymes as indicators of the metabolic compensation in diabetes.
BEHAVIOR OF SOME LYSOSOMAL-ENZYMES IN THE PLASMA OF INSULIN-DEPENDENT DIABETIC-PATIENTS DURING ARTIFICIAL PANCREAS TREATMENT / A. BURLINA, G. GOI, A. FABI, A. LOMBARDO, D. GABURRO, G. TETTAMANTI. - In: CLINICAL BIOCHEMISTRY. - ISSN 0009-9120. - 20:6(1987), pp. 423-427.
|Titolo:||BEHAVIOR OF SOME LYSOSOMAL-ENZYMES IN THE PLASMA OF INSULIN-DEPENDENT DIABETIC-PATIENTS DURING ARTIFICIAL PANCREAS TREATMENT|
GOI, GIANCARLO (Secondo)
TETTAMANTI, GUIDO (Ultimo)
|Parole Chiave:||artificial pancreas; diabetes; lysosomal enzymes; plasma clinical enzymology|
|Settore Scientifico Disciplinare:||Settore BIO/12 - Biochimica Clinica e Biologia Molecolare Clinica|
|Data di pubblicazione:||1987|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/0009-9120(87)90009-9|
|Appare nelle tipologie:||01 - Articolo su periodico|