An intensified CCD video camera has been used to measure the spatial distribution of the fluorescence decay time in tumor-bearing mice sensitized with hematoporphyrin derivative. Mice were injected with five doses of sensitizer, ranging from 0.1 to 10 mg/kg body weight. For any drug dose the decay time of the exogenous fluorescence in the tumor is always significantly longer than in normal tissues. The image created by associating a gray-shade scale to the decay time matrix of each mouse permits a reliable and precise detection of the neoplasia
Tumor detection in mice by measurement of fluorescence decay time matrices / R. Cubeddu, A. Pifferi, P. Taroni, G. Valentini, G. Canti. - In: OPTICS LETTERS. - ISSN 0146-9592. - 20:24(1995 Dec 15), p. 2553.
Tumor detection in mice by measurement of fluorescence decay time matrices
G. CantiUltimo
1995
Abstract
An intensified CCD video camera has been used to measure the spatial distribution of the fluorescence decay time in tumor-bearing mice sensitized with hematoporphyrin derivative. Mice were injected with five doses of sensitizer, ranging from 0.1 to 10 mg/kg body weight. For any drug dose the decay time of the exogenous fluorescence in the tumor is always significantly longer than in normal tissues. The image created by associating a gray-shade scale to the decay time matrix of each mouse permits a reliable and precise detection of the neoplasiaPubblicazioni consigliate
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