The cytocidal activity of light-activated mitoxantrone in mice bearing B16 melanoma was investigated. Mice inoculated with 10(6) tumor cells on day 0 were i.p. injected with 1 mg/kg body weight of mitoxantrone on days 1, 5 and 9 and exposed to 108 J/cm2 of suitably filtered red light from a halogen lamp on days 2, 6 and 10. The treatment significantly prolonged the median survival time compared to both therapy with mitoxantrone and with red light alone.
|Titolo:||B16 melanoma response in vivo to photochemotherapy with mitoxantrone and red light|
CANTI, GIANFRANCO (Secondo)
|Parole Chiave:||Neoplasm Transplantation; Animals; Melanoma, Experimental; Photochemotherapy; Mice, Inbred C57BL; Spectrophotometry; Mice; Light; Mitoxantrone; Male|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||9-dic-1991|
|Digital Object Identifier (DOI):||10.1016/0304-3835(91)90081-R|
|Appare nelle tipologie:||01 - Articolo su periodico|