The cytocidal activity of light-activated mitoxantrone in mice bearing B16 melanoma was investigated. Mice inoculated with 10(6) tumor cells on day 0 were i.p. injected with 1 mg/kg body weight of mitoxantrone on days 1, 5 and 9 and exposed to 108 J/cm2 of suitably filtered red light from a halogen lamp on days 2, 6 and 10. The treatment significantly prolonged the median survival time compared to both therapy with mitoxantrone and with red light alone.
B16 melanoma response in vivo to photochemotherapy with mitoxantrone and red light / A. Andreoni, G. Canti, G. Fabbrocini, M. Mastrocinque, E. Quarto. - In: CANCER LETTERS. - ISSN 0304-3835. - 61:1(1991 Dec 09), pp. 89-94.
B16 melanoma response in vivo to photochemotherapy with mitoxantrone and red light
G. CantiSecondo
;
1991
Abstract
The cytocidal activity of light-activated mitoxantrone in mice bearing B16 melanoma was investigated. Mice inoculated with 10(6) tumor cells on day 0 were i.p. injected with 1 mg/kg body weight of mitoxantrone on days 1, 5 and 9 and exposed to 108 J/cm2 of suitably filtered red light from a halogen lamp on days 2, 6 and 10. The treatment significantly prolonged the median survival time compared to both therapy with mitoxantrone and with red light alone.
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