Pantethine was tested in different forms of experimental hyperlipidemia in a rodent strain (Ivanovas-Sieve) spontaneously exhibiting elevated plasma triglyceride (TG) levels. Pantethine (P) generally given at a daily dose of 500 mg/kg, was compared with clofibrate (200 mg/kg). P and clofibrate (CPIB) proved ineffective on ACTH lipolysis and on Triton hyperlipidemia; CPIB showed a significant activity on fructose and ethanol induced hypertriglyceridemia; both compounds effectively reduced elevated TG and cholesterol levels following the Nath diet. In all experimental models, both in basal conditions and after stimulation, CPIB generally reduced high density lipoprotein cholesterol (HDL-C) levels; this effect was not elicited by P.
Effects of pantethine on different models of experimental hyperlipidemia in rodents: a comparison with clofibrate / R. Farina, M. R. Lovati, G. Raucci, C. R. Sirtori. - In: PHARMACOLOGICAL RESEARCH COMMUNICATIONS. - ISSN 0031-6989. - 14:6(1982 Jun), pp. 499-510.
|Titolo:||Effects of pantethine on different models of experimental hyperlipidemia in rodents: a comparison with clofibrate|
LOVATI, MARIA ROSA (Secondo)
SIRTORI, CESARE (Ultimo)
|Parole Chiave:||Rats; Clofibrate; Animals; Sulfhydryl Compounds; Hyperlipidemias; Hypolipidemic Agents; Pantetheine; Lipoproteins, HDL; Disease Models, Animal; Male|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||giu-1982|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/S0031-6989(82)80040-4|
|Appare nelle tipologie:||01 - Articolo su periodico|