Pantethine was tested in different forms of experimental hyperlipidemia in a rodent strain (Ivanovas-Sieve) spontaneously exhibiting elevated plasma triglyceride (TG) levels. Pantethine (P) generally given at a daily dose of 500 mg/kg, was compared with clofibrate (200 mg/kg). P and clofibrate (CPIB) proved ineffective on ACTH lipolysis and on Triton hyperlipidemia; CPIB showed a significant activity on fructose and ethanol induced hypertriglyceridemia; both compounds effectively reduced elevated TG and cholesterol levels following the Nath diet. In all experimental models, both in basal conditions and after stimulation, CPIB generally reduced high density lipoprotein cholesterol (HDL-C) levels; this effect was not elicited by P.

Effects of pantethine on different models of experimental hyperlipidemia in rodents: a comparison with clofibrate / R. Farina, M. R. Lovati, G. Raucci, C. R. Sirtori. - In: PHARMACOLOGICAL RESEARCH COMMUNICATIONS. - ISSN 0031-6989. - 14:6(1982 Jun), pp. 499-510.

Effects of pantethine on different models of experimental hyperlipidemia in rodents: a comparison with clofibrate

M. R. Lovati
Secondo
;
C. R. Sirtori
Ultimo
1982

Abstract

Pantethine was tested in different forms of experimental hyperlipidemia in a rodent strain (Ivanovas-Sieve) spontaneously exhibiting elevated plasma triglyceride (TG) levels. Pantethine (P) generally given at a daily dose of 500 mg/kg, was compared with clofibrate (200 mg/kg). P and clofibrate (CPIB) proved ineffective on ACTH lipolysis and on Triton hyperlipidemia; CPIB showed a significant activity on fructose and ethanol induced hypertriglyceridemia; both compounds effectively reduced elevated TG and cholesterol levels following the Nath diet. In all experimental models, both in basal conditions and after stimulation, CPIB generally reduced high density lipoprotein cholesterol (HDL-C) levels; this effect was not elicited by P.
Rats; Clofibrate; Animals; Sulfhydryl Compounds; Hyperlipidemias; Hypolipidemic Agents; Pantetheine; Lipoproteins, HDL; Disease Models, Animal; Male
Settore BIO/14 - Farmacologia
giu-1982
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/191538
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