We propose a renal imaging agent, the 99mTc complex of the bidentate-N,S chelate N-(mercaptoacetyl)glycine (99mTc-2GAM), with the imaging characteristics of 99mTc-DMSA but a faster kidney uptake; chemical evidence supports the formulation of 99mTc-2GAM as [Tc(v)(O)(GAM)2]-. After biodistribution and toxicity studies in animals, 99mTc-2GAM was evaluated in five normal volunteers. 99mTc-2GAM is rapidly cleared from the blood (t1/2 = 9 min) and 50% of the ID is excreted in the urine in the first 2 h. Dynamic data show a rapid renal uptake that increases up to 1 h with no significant wash-out between 1 and 8 h. The uptake in each kidney ranges from 11.3% to 20.7% ID. Low, stable liver uptake is observed. No significant activity is detected in other organs. We showed no differences between 99mTc-2GAM and 99mTc-DMSA compared in three patients with unilateral kidney disease. We conclude that 99mTc-2GAM has good practical and dosimetric features for renal imaging.
99mTc-2GAM: a tracer for renal imaging / L. Gianolli, F. Dosio, M. Matarrese, F. Colombo, C. Cutler, D. Stepniak-Biniakiewicz, E. Deutsch, A. Savi, G. Lucignani, F. Fazio. - In: NUCLEAR MEDICINE AND BIOLOGY. - ISSN 0969-8051. - 23:8(1996 Nov), pp. 927-33-933.
|Titolo:||99mTc-2GAM: a tracer for renal imaging|
LUCIGNANI, GIOVANNI (Penultimo)
|Parole Chiave:||DMSA; renal imaging; renal mass|
|Settore Scientifico Disciplinare:||Settore MED/36 - Diagnostica per Immagini e Radioterapia|
|Data di pubblicazione:||nov-1996|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/S0969-8051(96)00135-7|
|Appare nelle tipologie:||01 - Articolo su periodico|