Lymphocyte subpopulations were studied in 16 myasthenic patients by means of E and EA7s rosettes and surface membrane immunofluorescence. Myasthenic patients showed an increase in lymphocytes with surface IgM an IgD when compared to a control group. In female patients this increase was highly significant, and lymphocytes bearing membrane IgG and IgA were also augmented. No difference was found in male patients when compared with sex-matched controls. These results suggest an activation of the B cell compartment restricted to female patients, and support the hypothesis of different immunopathogenetic mechanisms in this disease.

Lymphocyte subpopulations and surface membrane immunoglobulins in myasthenia gravis / G. Landi, M. Galli, G. Ciboddo, G. Colombo, G. Scarlato. - In: JOURNAL OF NEUROLOGY, NEUROSURGERY AND PSYCHIATRY. - ISSN 0022-3050. - 45:2(1982 Feb), pp. 158-161.

Lymphocyte subpopulations and surface membrane immunoglobulins in myasthenia gravis

M. Galli
Secondo
;
1982

Abstract

Lymphocyte subpopulations were studied in 16 myasthenic patients by means of E and EA7s rosettes and surface membrane immunofluorescence. Myasthenic patients showed an increase in lymphocytes with surface IgM an IgD when compared to a control group. In female patients this increase was highly significant, and lymphocytes bearing membrane IgG and IgA were also augmented. No difference was found in male patients when compared with sex-matched controls. These results suggest an activation of the B cell compartment restricted to female patients, and support the hypothesis of different immunopathogenetic mechanisms in this disease.
Sex Factors; Humans; Lymphocytes; Receptors, Antigen, B-Cell; Leukocyte Count; Adult; Cell Membrane; Rosette Formation; Middle Aged; Myasthenia Gravis; Fluorescent Antibody Technique; Female; Male
Settore MED/17 - Malattie Infettive
Settore MED/26 - Neurologia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/191230
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