The interleukin-1 (IL-1) family of cytokines is involved in the inflammatory and repair reactions of skeletal muscle during and after exercise. Specifically, plasma levels of the IL-1 receptor antagonist (IL-1ra) increase dramatically after intense exercise, and accumulating evidence points to an effect of genetic polymorphisms on athletic phenotypes. Therefore, the IL-1 family cytokine genes are plausible candidate genes for athleticism. We explored whether IL-1 polymorphisms are associated with athlete status in European subjects.

Variable number of tandem repeat polymorphisms of the interleukin-1 receptor antagonist gene IL-1RN: a novel association with the athlete status / S. Cauci, M. Di Santolo, K. K. Ryckman, S. M. Williams, G. Banfi. - In: BMC MEDICAL GENETICS. - ISSN 1471-2350. - 11:1(2010). [10.1186/1471-2350-11-29]

Variable number of tandem repeat polymorphisms of the interleukin-1 receptor antagonist gene IL-1RN: a novel association with the athlete status

G. Banfi
Ultimo
2010

Abstract

The interleukin-1 (IL-1) family of cytokines is involved in the inflammatory and repair reactions of skeletal muscle during and after exercise. Specifically, plasma levels of the IL-1 receptor antagonist (IL-1ra) increase dramatically after intense exercise, and accumulating evidence points to an effect of genetic polymorphisms on athletic phenotypes. Therefore, the IL-1 family cytokine genes are plausible candidate genes for athleticism. We explored whether IL-1 polymorphisms are associated with athlete status in European subjects.
Odds Ratio ; Gene Frequency ; Polymorphism, Genetic ; Humans ; Interleukin-1beta ; Muscle, Skeletal ; Phenotype ; Minisatellite Repeats ; Genotype ; Promoter Regions, Genetic ; Alleles ; Haplotypes ; Adult ; Introns ; Interleukin 1 Receptor Antagonist Protein ; Female ; Male ; Athletes
Settore BIO/12 - Biochimica Clinica e Biologia Molecolare Clinica
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/191154
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