In severe cystic acne we found low levels of high density lipoprotein-cholesterol (HDL-C) and apolipoprotein A (Apo-A) in the presence of normal total lipids. In a larger number of patients, we always observed significantly lower levels of HDL-C and Apo-A than in either age-matched controls or subjects with acne vulgaris. Since lipoprotein lipase is one major determinant of HDL concentration, we assayed the lipase activity in liver and extra-hepatic tissues by the method of Krauss et al. There was highly significant less total and hepatic lipase activity than in age-matched controls. HDL distribution was examined by zonal ultracentrifugation and a decrease in the HDL2 subclass was discovered. Since HDL are inversely correlated to atherosclerosis, cystic acne is one risk factor for atherosclerosis. The linkage between low HDL levels and severe cystic acne should be further investigated.
Lipoprotein metabolism and lipoprotein lipase in severe cystic acne / P. Pigatto, G. F. Altomare, M. Negri, A. F. Finzi, G. Vigotti, C. Vergani. - In: DERMATOLOGICA. - ISSN 0011-9075. - 171:4(1985), pp. 243-6-246.
|Titolo:||Lipoprotein metabolism and lipoprotein lipase in severe cystic acne|
PIGATTO, PAOLO DANIELE MARIA (Primo)
ALTOMARE, GIANFRANCO (Secondo)
VERGANI, CARLO (Ultimo)
|Parole Chiave:||Lipoprotein Lipase; Cholesterol, HDL; Humans; Lipoproteins; Apolipoproteins A; Adult; Liver; Cysts; Male; Acne Vulgaris|
|Settore Scientifico Disciplinare:||Settore MED/09 - Medicina Interna|
Settore MED/35 - Malattie Cutanee e Veneree
|Data di pubblicazione:||1985|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1159/000249430|
|Appare nelle tipologie:||01 - Articolo su periodico|