Pituitary-thyroid function has been studied in heroin addicts. Data have been obtained in 10 male addicts, aged 18-24 years, with histories of addiction to heroin alone lasting from 8 months to 4 years, and in 9 controls matched for sex and age. Basal plasma levels of TSH, T4 and T3 were measured. A TRH stimulation test was done, injecting 500 micrograms of TRH iv as a bolus and assaying TSH levels before the injection and at 30 min intervals up to 2 h afterwards. The results revealed no difference between addicts and controls in basal levels of TSH, T4 and T3. The TRH stimulation test induced a blunted TSH rise in 50% of the cases. The possible mechanism of action of heroin on pituitary-thyroid axis is discussed.

Effects of chronic heroin addiction on pituitary-thyroid function in man / F. Brambilla, P. Nobile, A. Zanoboni, W. Zanoboni-Muciaccia, P. L. Meroni. - In: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. - ISSN 0391-4097. - 3:3(1980 Jul), pp. 251-255.

Effects of chronic heroin addiction on pituitary-thyroid function in man

P. L. Meroni
Ultimo
1980

Abstract

Pituitary-thyroid function has been studied in heroin addicts. Data have been obtained in 10 male addicts, aged 18-24 years, with histories of addiction to heroin alone lasting from 8 months to 4 years, and in 9 controls matched for sex and age. Basal plasma levels of TSH, T4 and T3 were measured. A TRH stimulation test was done, injecting 500 micrograms of TRH iv as a bolus and assaying TSH levels before the injection and at 30 min intervals up to 2 h afterwards. The results revealed no difference between addicts and controls in basal levels of TSH, T4 and T3. The TRH stimulation test induced a blunted TSH rise in 50% of the cases. The possible mechanism of action of heroin on pituitary-thyroid axis is discussed.
Pituitary Gland; Heroin Dependence; Humans; Adult; Chronic Disease; Thyroid Gland; Adolescent; Male
Settore MED/16 - Reumatologia
http://www.jendocrinolinvest.it/jei/it/
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/190613
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