Beta-interferon was administered by intravenous infusion to 16 patients affected with fulminant hepatitis B virus infection in third or fourth-grade coma. Ten patients presented a superinfection or a co-infection due to the delta (delta)-agent. None had detectable interferon (IFN) activity before therapy was begun. Besides fever, no significant side-effects were observed during treatment. Both the IFN-treated group as well as the "historical" control group, made up of 70 cases of fulminant virus hepatitis, not treated with IFN and observed during a previous ten year-period, received supportive therapy; survival rates were similar in both groups. Furthermore, the presence or absence of the delta-agent did not appear to affect survival rates significantly.
Attempted treatment of fulminant viral hepatitis with human fibroblast interferon / F. Milazzo, M. Galli, P. G. Fassio, A. Cargnel, A. Pugliese, P. A. Tovo, G. M. Vigevani, R. Esposito, A. Lazzarin, F. Caredda. - In: INFECTION. - ISSN 0300-8126. - 13:3(1985), pp. 130-133.
|Titolo:||Attempted treatment of fulminant viral hepatitis with human fibroblast interferon|
GALLI, MASSIMO (Secondo)
LAZZARIN, ADRIANO (Penultimo)
|Parole Chiave:||Hepatitis B Antigens; Humans; Adult; Interferon Type I; Hepatitis B; Clinical Trials as Topic; Hepatitis delta Antigens; Adolescent; Infusions, Parenteral; Male; Female|
|Settore Scientifico Disciplinare:||Settore MED/17 - Malattie Infettive|
|Data di pubblicazione:||1985|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/BF01642872|
|Appare nelle tipologie:||01 - Articolo su periodico|