Vasculitis complicating Cystic Fibrosis (CF) has been rarely reported. We describe a case of CF patient with a generalised Schoenlein-Henoch Purpura (SHP) characterised by neurological, kydney and cardiac involvement. Given the immunological origin of the vasculitis, CF patients present some conditions that can induce an hyperergic immune response: bronchial chronic microbial infection, prolonged antibiotic treatment, pancreatic enzymes, bronchodilators, mucolytics and other drugs, are factors that represent a considerable antigenic reserve, on the other hand, the constant increase of serum immunoglobulin levels and sometimes of circulating immunecomplexes seem to facilitate the onset of vasculitis, especially SHP, in this group of patients.

Sindrome di Schoenlein-Henoch / L. Gnecchi, P. Randi, G. Rizzitelli, S. Veraldi - In: Dermatologia clinica : 300 casi inusuali presentati agli “Incontri Dermatologici” di Segrate / T. Cainelli, L. Marchesi. - Milano : McGraw-Hill Libri Italia, 2000. - ISBN 8838629595. - pp. 298-299

Sindrome di Schoenlein-Henoch

S. Veraldi
Ultimo
2000

Abstract

Vasculitis complicating Cystic Fibrosis (CF) has been rarely reported. We describe a case of CF patient with a generalised Schoenlein-Henoch Purpura (SHP) characterised by neurological, kydney and cardiac involvement. Given the immunological origin of the vasculitis, CF patients present some conditions that can induce an hyperergic immune response: bronchial chronic microbial infection, prolonged antibiotic treatment, pancreatic enzymes, bronchodilators, mucolytics and other drugs, are factors that represent a considerable antigenic reserve, on the other hand, the constant increase of serum immunoglobulin levels and sometimes of circulating immunecomplexes seem to facilitate the onset of vasculitis, especially SHP, in this group of patients.
Cystic Fibrosis; Schoenlein-Henoch Purpura
Settore MED/35 - Malattie Cutanee e Veneree
Book Part (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/190551
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