Iron supplements can interfere with the bioavailability of a number of drugs, including thyroxine, tetracycline derivatives, penicillamine, methyldopa, levodopa, carbidopa, ciprofloxacin, and the newer fluoroquinolones. A new iron formulation was tested in which iron ions are bound to ovotransferrin, a protein that shares more than an 80% similarity with the sequence of human transferrin and apparently is less likely than the commonly used iron salts to reduce drug absorption. Ciprofloxacin was taken as a model drug, of wide use and restricted range of therapeutic levels, and its absorption was evaluated after the administration of the iron-ovotransferrin complex versus an iron-gluconate formulation in healthy volunteers. At variance with the iron gluconate formulation, which led to a reduction of about 50% of peak serum ciprofloxacin levels (Cmax; 1.0 +/- 0.2 versus 2.4 +/- 0.3 micrograms/ml; p < 0.01) and of the area under the serum concentration-time curve from time 0 to infinity [AUC(0 - infinity); 10.1 +/- 1.1 versus 18.3 +/- 1.0 mg.L-1.hr; p < 0.01], the iron-ovotransferrin complex caused only modest, non significant changes in absorption with a minimal reduction of the AUC[0 - infinity) (17.3 +/- 1.0 versus 18.3 +/- 1.0 mg.L-1.hr; difference not significant) and a nonsignificant decrease in the Cmax (2.2 +/- 0.3 versus 2.4 +/- 0.3 microgram/ml; difference not significant). Iron was also well absorbed from the formulation in the presence of a fatty meal. The very common drug interactions with oral iron preparations can be effectively prevented by the use of the iron-ovotransferrin complex interacting to a minimal extent with a sensitive drug with a reduced margin of efficacy, such as ciprofloxacin.
Iron-ovotransferrin preparation does not interfere with ciprofloxacin absorption / F. Pazzucconi, S. Barbi, D. Baldassarre, N. Colombo, F. Dorigotti, C.R. Sirtori. - In: CLINICAL PHARMACOLOGY & THERAPEUTICS. - ISSN 0009-9236. - 59:4(1996 Apr), pp. 418-422.
|Titolo:||Iron-ovotransferrin preparation does not interfere with ciprofloxacin absorption|
PAZZUCCONI, FRANCO (Primo)
SIRTORI, CESARE (Ultimo)
|Parole Chiave:||Iron Compounds ; Ciprofloxacin ; Anti-Infective Agents ; Reference Values ; Humans ; Conalbumin ; Adult ; Middle Aged ; Intestinal Absorption ; Male ; Drug Combinations|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||apr-1996|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/S0009-9236(96)90110-1|
|Appare nelle tipologie:||01 - Articolo su periodico|