A mutant (TTC1) derived from Pseudomonas fluorescens N3 has been obtained for use in the bioconversion of several naphthalene derivatives to the corresponding optically active cis-dihydrodiols on a milligrams-to-grams scale. All main compounds have been characterized, their relative and absolute configuration assigned, and their enantiomeric purity determined. The regio- and stereoselectivity of the transformation has been established. The procedure therefore represents a valid method for the convenient preparation of a pool of valuable chiral syntons and auxiliaries.

Bioconversion of substituted naphthalenes to the corresponding 1,2-dihydro-1,2-dihydroxy derivatives. Determination of the regio- and stereochemistry of the oxidation reactions / G. Bestetti, D. Bianchi, A. Bosetti, P. Gennaro, E. Galli, B. Leoni, F. Pelizzoni, G. Sello. - In: APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. - ISSN 0175-7598. - 44:3-4(1995), pp. 306-313.

Bioconversion of substituted naphthalenes to the corresponding 1,2-dihydro-1,2-dihydroxy derivatives. Determination of the regio- and stereochemistry of the oxidation reactions

E. Galli;G. Sello
Ultimo
1995

Abstract

A mutant (TTC1) derived from Pseudomonas fluorescens N3 has been obtained for use in the bioconversion of several naphthalene derivatives to the corresponding optically active cis-dihydrodiols on a milligrams-to-grams scale. All main compounds have been characterized, their relative and absolute configuration assigned, and their enantiomeric purity determined. The regio- and stereoselectivity of the transformation has been established. The procedure therefore represents a valid method for the convenient preparation of a pool of valuable chiral syntons and auxiliaries.
microbial oxidation
Settore CHIM/06 - Chimica Organica
Settore BIO/11 - Biologia Molecolare
Settore BIO/19 - Microbiologia Generale
Settore CHIM/11 - Chimica e Biotecnologia delle Fermentazioni
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/190156
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