To evaluate the role of thrombin and the involvement of endothelin-1 (ET-1) in regulation of bronchomotor and vascular tone, we used 18 anaesthetised, mechanically ventilated pigs, divided into three groups. Group 1 (n = 6) was treated with E. coli LPS (20 microng/kg/h for 180 min); group 2 (n = 6) was infused with a thrombin inhibitor and LPS was administered similarly to group 1; group 3 (n = 6) was pre-treated with a dual ET-1 receptors blocking agent (20 mg/kg i.v.), before endotoxic shock. In presence of the thrombin inhibitor, the LPS-dependent pulmonary hypertension was still present, also if it was less important, and the changes in C sub (L) and R sub (L) were similar to that observed in group 1. The dual block of ET-1 receptors, at contrary, completely abolished the pulmonary hypertension, the changes in C sub (L) and R sub (L), due to LPS infusion, but worsened the systemic hypotension

Azione agonistica della trombina e dell’endotelina nella regolazione del tono vasomotore e broncomotore nel suino / B. Ciminaghi, M. ALbertini, S. Mazzola, M.G. Clement. - In: ATTI DELLA SOCIETA' ITALIANA DELLE SCIENZE VETERINARIE. - ISSN 1721-1980. - 56(2002), pp. 75-76. ((Intervento presentato al 56. convegno LVI Congresso SISVet tenutosi a Giardini Naxos, Messina nel 2002.

Azione agonistica della trombina e dell’endotelina nella regolazione del tono vasomotore e broncomotore nel suino

M. ALbertini;S. Mazzola;M.G. Clement
2002

Abstract

To evaluate the role of thrombin and the involvement of endothelin-1 (ET-1) in regulation of bronchomotor and vascular tone, we used 18 anaesthetised, mechanically ventilated pigs, divided into three groups. Group 1 (n = 6) was treated with E. coli LPS (20 microng/kg/h for 180 min); group 2 (n = 6) was infused with a thrombin inhibitor and LPS was administered similarly to group 1; group 3 (n = 6) was pre-treated with a dual ET-1 receptors blocking agent (20 mg/kg i.v.), before endotoxic shock. In presence of the thrombin inhibitor, the LPS-dependent pulmonary hypertension was still present, also if it was less important, and the changes in C sub (L) and R sub (L) were similar to that observed in group 1. The dual block of ET-1 receptors, at contrary, completely abolished the pulmonary hypertension, the changes in C sub (L) and R sub (L), due to LPS infusion, but worsened the systemic hypotension
Settore VET/02 - Fisiologia Veterinaria
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/189943
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