Argyrophilic tumors were diagnosed in 28 of 134 (20.8%) consecutive male patients who had a carcinoma of the breast removed between 1961 and 1990. Histologically, most argyrophilic tumors showed uniform cellularity and prevalent expansive growth. Ultrastructural observation disclosed the presence of electron-dense cored granules in the cytoplasm of the tumor cells. By immunocytochemistry, 17 of 28 argyrophilic tumors (60.7%) contained chromogranin B (secretogranin I)-immunoreactive cells, whereas chromogranin A was present in four of these 17 tumors only (14.2%). Immunoblotting studies showed chromogranin B immunoreactivity similar to that found in normal neuroendocrine cells. Despite these findings, which would argue for a distinct morphologic and immunochemical entity, no statistically significant differences between argyrophilic and common male breast carcinomas were found when a number of clinicopathologic features and relapse-free survival were considered.
|Titolo:||Argyrophilic carcinoma of the male breast. A neuroendocrine tumor containing predominantly chromogranin B (secretogranin I)|
|Parole Chiave:||Immunoblotting; Sex Factors; Chromogranin B; Chromogranin A; Humans; Chromogranins; Aged; Breast Neoplasms; Aged, 80 and over; Adult; Middle Aged; Immunohistochemistry; Neurosecretory Systems; Male; Survival Analysis|
|Settore Scientifico Disciplinare:||Settore MED/01 - Statistica Medica|
|Data di pubblicazione:||nov-1991|
|Digital Object Identifier (DOI):||10.1097/00000478-199111000-00005|
|Appare nelle tipologie:||01 - Articolo su periodico|