p53 gene mutation and p53 protein accumulation are common in human cancer. However, their clinical significance is controversial and p53 accumulation may not correlate with gene mutation. The current study investigates the occurrence of p53 alterations in esophageal carcinoma, the correlation between the analyses at the gene and protein level, and their prognostic significance.
p53 protein accumulation and p53 gene mutation in esophageal carcinoma. A molecular and immunohistochemical study with clinicopathologic correlations / G. Coggi, S. Bosari, M. Roncalli, D. Graziani, P. Bossi, G. Viale, R. Buffa, S. Ferrero, M. Piazza, S. Blandamura, A. Segalin, L. Bonavina, A. Peracchia. - In: CANCER. - ISSN 0008-543X. - 79:3(1997 Feb 01), pp. 425-432. [10.1002/(SICI)1097-0142(19970201)79:3<425::AID-CNCR1>3.0.CO;2-H]
p53 protein accumulation and p53 gene mutation in esophageal carcinoma. A molecular and immunohistochemical study with clinicopathologic correlations
S. BosariSecondo
;M. Roncalli;G. Viale;S. Ferrero;L. BonavinaPenultimo
;
1997
Abstract
p53 gene mutation and p53 protein accumulation are common in human cancer. However, their clinical significance is controversial and p53 accumulation may not correlate with gene mutation. The current study investigates the occurrence of p53 alterations in esophageal carcinoma, the correlation between the analyses at the gene and protein level, and their prognostic significance.
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