A series of 2-substituted 4,5-functionalized 6-phenyl-3(2H)-pyridazinones were synthesized and their antinociceptive activities were evaluated in the mouse abdominal constriction model. Single dose studies showed that compounds 11, 18a and 23 were more active than the reference drug, Emorfazone, in inhibiting the effects of the noxious chemical stimulus, p-phenylquinone. Subsequent dose-response studies revealed 18a to be almost seven-fold more potent than Emorfazone.
4,5-Functionalized 6-phenyl-3(2H)pyridazinones: synthesis and evaluation of antinociceptive activity / V. Dal Piaz, M.P. Giovannoni, G. Ciciani, D. Barlocco, G. Giardina, G. Petrone, G.D. Clarke. - In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0223-5234. - 31:1(1996), pp. 65-70.
4,5-Functionalized 6-phenyl-3(2H)pyridazinones: synthesis and evaluation of antinociceptive activity
D. Barlocco;
1996
Abstract
A series of 2-substituted 4,5-functionalized 6-phenyl-3(2H)-pyridazinones were synthesized and their antinociceptive activities were evaluated in the mouse abdominal constriction model. Single dose studies showed that compounds 11, 18a and 23 were more active than the reference drug, Emorfazone, in inhibiting the effects of the noxious chemical stimulus, p-phenylquinone. Subsequent dose-response studies revealed 18a to be almost seven-fold more potent than Emorfazone.
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
