A series of 2-substituted 4,5-functionalized 6-phenyl-3(2H)-pyridazinones were synthesized and their antinociceptive activities were evaluated in the mouse abdominal constriction model. Single dose studies showed that compounds 11, 18a and 23 were more active than the reference drug, Emorfazone, in inhibiting the effects of the noxious chemical stimulus, p-phenylquinone. Subsequent dose-response studies revealed 18a to be almost seven-fold more potent than Emorfazone.
|Titolo:||4,5-Functionalized 6-phenyl-3(2H)pyridazinones: synthesis and evaluation of antinociceptive activity|
|Parole Chiave:||Antinociceptive activity; Emorfazone; Pyridazinone|
|Settore Scientifico Disciplinare:||Settore CHIM/08 - Chimica Farmaceutica|
|Data di pubblicazione:||1996|
|Digital Object Identifier (DOI):||10.1016/S0223-5234(96)80008-0|
|Appare nelle tipologie:||01 - Articolo su periodico|