A new, microporous, uniformly reticulated preparation of cholestyramine is described. The preparation, cholpor, has a higher exchange capacity for chloride than does cholestyramine and swells very little in water. It is 15--20% more potent than chloestyramine in the in vitro binding of sodium cholate; moreover, the binding velocity is considerably higher than that of cholestyramine. Colestipol hydrochloride, also used as a reference anion-exchange resin, is about half as potent as the other two resins; its binding velocity is similar to that of cholpor. Cholpor may be prepared in a suspension form of good palatability. Preliminary clinical findings in short-term trials showed a cholesterol-lowering effect similar to that of cholestyramine with lower doses and fewer side effects.

New microporous cholestyramine analog for treatment of hypercholesterolemia / R. De Simone, F. Conti, M. R. Lovati, M. Sirtori, E. Cocuzza, C. R. Sirtori. - In: JOURNAL OF PHARMACEUTICAL SCIENCES. - ISSN 0022-3549. - 67:12(1978 Dec), pp. 1695-1698.

New microporous cholestyramine analog for treatment of hypercholesterolemia

M. R. Lovati;C. R. Sirtori
Ultimo
1978

Abstract

A new, microporous, uniformly reticulated preparation of cholestyramine is described. The preparation, cholpor, has a higher exchange capacity for chloride than does cholestyramine and swells very little in water. It is 15--20% more potent than chloestyramine in the in vitro binding of sodium cholate; moreover, the binding velocity is considerably higher than that of cholestyramine. Colestipol hydrochloride, also used as a reference anion-exchange resin, is about half as potent as the other two resins; its binding velocity is similar to that of cholpor. Cholpor may be prepared in a suspension form of good palatability. Preliminary clinical findings in short-term trials showed a cholesterol-lowering effect similar to that of cholestyramine with lower doses and fewer side effects.
Cholic Acids; Suspensions; Humans; Colestipol; Adult; Constipation; Aged; Middle Aged; Cholestyramine Resin; Hypercholesterolemia; Male; Female
Settore BIO/14 - Farmacologia
dic-1978
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/189383
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