Two cases of sarcoid polyneuropathy were diagnosed by histological examination of the nerve biopsy. The electrophysiological findings in both patients suggested a neuropathy of axonal type, confirmed by a morphological study of a sural nerve biopsy by light microscopy and on teased-fiber preparations. The sarcoid granulomas were multiple, especially in case 2; they were sparse in the epineurial and perineurial spaces and absent in the endoneurium, whose interstitial component contained cellular infiltrations of scattered macrophages. Blood vessel changes were a constant morphological feature. The mechanisms that possibly contribute to the pathogenesis of the sarcoid neuropathy are discussed in relation to previous reports.

Sarcoidosis of the peripheral nerve: clinical, electrophysiological and histological study of two cases / G. Galassi, M. Gibertoni, A. Mancini, R. Nemni, G. Volpi, E. Merelli, G. Vacca. - In: EUROPEAN NEUROLOGY. - ISSN 0014-3022. - 23:6(1984), pp. 459-65-465.

Sarcoidosis of the peripheral nerve: clinical, electrophysiological and histological study of two cases

R. Nemni;
1984

Abstract

Two cases of sarcoid polyneuropathy were diagnosed by histological examination of the nerve biopsy. The electrophysiological findings in both patients suggested a neuropathy of axonal type, confirmed by a morphological study of a sural nerve biopsy by light microscopy and on teased-fiber preparations. The sarcoid granulomas were multiple, especially in case 2; they were sparse in the epineurial and perineurial spaces and absent in the endoneurium, whose interstitial component contained cellular infiltrations of scattered macrophages. Blood vessel changes were a constant morphological feature. The mechanisms that possibly contribute to the pathogenesis of the sarcoid neuropathy are discussed in relation to previous reports.
Humans; Electromyography; Muscles; Polyneuropathies; Aged; Sarcoidosis; Sensation; Peripheral Nervous System Diseases; Sural Nerve; Neural Conduction; Axons; Microscopy, Electron; Middle Aged; Male; Motor Neurons
Settore MED/26 - Neurologia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/189256
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