Prothrombin time (PT) is the primary laboratory test for monitoring oral anticoagulant treatment but is influenced by preanalytical conditions and analytical variables, that is, thromboplastin reagents and instrumentation. Standardization and normalization of test results is mandatory. PT results should be transformed to International Normalized Ratio (INR) by calibration of the reagent/instrument system with International Reference standards according to World Health Organization guidelines. However, there is still uncertainty in the INR that is caused in part by calibration errors and in part by interaction between the PT reagent and various factors in the patient's specimen. These problems are highlighted in INR measurements performed with whole blood coagulation monitors. Each center should maintain an appropriate scheme of internal and external quality control for the laboratory INR measurement as well as the individual point-of-care coagulation monitors used by the center and patients for self-testing.

Oral anticoagulant monitoring by laboratory or near patient testing: what a clinician should be aware of / A. Tripodi, W.G.M. Breukink-Engbers, A.M.H.P. van den Besselaar. - In: SEMINARS IN VASCULAR MEDICINE. - ISSN 1528-9648. - 3:3(2003), pp. 243-254.

Oral anticoagulant monitoring by laboratory or near patient testing: what a clinician should be aware of

A. Tripodi;
2003

Abstract

Prothrombin time (PT) is the primary laboratory test for monitoring oral anticoagulant treatment but is influenced by preanalytical conditions and analytical variables, that is, thromboplastin reagents and instrumentation. Standardization and normalization of test results is mandatory. PT results should be transformed to International Normalized Ratio (INR) by calibration of the reagent/instrument system with International Reference standards according to World Health Organization guidelines. However, there is still uncertainty in the INR that is caused in part by calibration errors and in part by interaction between the PT reagent and various factors in the patient's specimen. These problems are highlighted in INR measurements performed with whole blood coagulation monitors. Each center should maintain an appropriate scheme of internal and external quality control for the laboratory INR measurement as well as the individual point-of-care coagulation monitors used by the center and patients for self-testing.
International Normalized Ratio; Near-patient testing; Oral anticoagulation
Settore AGR/16 - Microbiologia Agraria
Settore MED/09 - Medicina Interna
Settore MED/15 - Malattie del Sangue
SEMINARS IN VASCULAR MEDICINE
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/189219
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