Thirty-four patients with AIDS-related complex (ARC) were treated for 6 months with thymostimulin, a thymic hormone. Clinical and immunological findings after a 1-year follow-up were compared with those in 24 age- and sex-matched controls receiving no immunotherapy. Statistical evaluation after 6 and 12 months showed significant differences in the two groups. The thymostimulin-treated group had higher leukocyte and lymphocyte counts, more positivity in intradermal tests with multiple recall antigens, and less lymphadenopathy and weight loss. The number of OKT3+ and OKT4+ lymphocytes decreased significantly in the control group, but did not change in the thymostimulin-treated patients. Finally, after 18 months of follow-up, no progression to AIDS was seen among the treated subjects, whereas 3 of the controls developed the disease. We conclude that thymostimulin, alone or in combination with antiviral drugs, may be helpful in the management of ARC patients.
|Titolo:||Thymostimulin treatment in AIDS-related complex|
|Parole Chiave:||Body Weight; Antigens, Differentiation, T-Lymphocyte; Immunotherapy; Humans; Substance-Related Disorders; AIDS-Related Complex; Homosexuality; Thymus Extracts; Leukocyte Count|
|Settore Scientifico Disciplinare:||Settore MED/17 - Malattie Infettive|
|Data di pubblicazione:||giu-1988|
|Digital Object Identifier (DOI):||10.1016/S0090-1229(88)80003-5|
|Appare nelle tipologie:||01 - Articolo su periodico|