A panel of chimpanzee-human somatic cell hybrids was characterized by dual Alu-PCR of the chimpanzee DNA in the hybrid and subsequent hybridization of the labeled PCR products to human and chimpanzee chromosomes. In addition to the identification of the intact chimpanzee chromosomes retained in each hybrid chromosome fragments were identified that will be useful in regional mapping. This technique also revealed the presence of centric inversions.
Characterization of chimpanzee-hamster hybrids by chromosome painting / N. Archidiacono, R. Marzella, P. Finelli, R. Antonacci, C. Jones, M. Rocchi. - In: SOMATIC CELL AND MOLECULAR GENETICS. - ISSN 0740-7750. - 20:5(1994 Sep), pp. 439-442.
Characterization of chimpanzee-hamster hybrids by chromosome painting
P. Finelli;
1994
Abstract
A panel of chimpanzee-human somatic cell hybrids was characterized by dual Alu-PCR of the chimpanzee DNA in the hybrid and subsequent hybridization of the labeled PCR products to human and chimpanzee chromosomes. In addition to the identification of the intact chimpanzee chromosomes retained in each hybrid chromosome fragments were identified that will be useful in regional mapping. This technique also revealed the presence of centric inversions.
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