The N-methyl-d-aspartate (NMDA) receptor channel is essential for synaptic transmission and synaptic plasticity underlying memory, learning, and development. Three subunits of the NMDA receptor channel, NMDAR2A, NMDAR2B, and NMDAR2C (NR2A, NR2B, and NR2C), previously identified in mouse by cDNA cloning and expression, share a high level of homology, although their patterns of expression within the brain may differ. In the present work we report the localization of the gene encoding the human NMDAR2B receptor subunit (called GRIN2B for glutamate receptor, ionotropic, N -methyl-d-aspartate 2B) to chromosome 12p12 by in situ hybridization and somatic cell hybrids.

Mapping of the Human NMDAR2B Receptor Subunit Gene (GRIN2B) to Chromosome 12p12 / P. Mandich, A.M. Schito, E. Bellone, R. Antonacci, P. Finelli, M. Rocchi, F. Ajmar. - In: GENOMICS. - ISSN 0888-7543. - 22:1(1994 Jul), pp. 216-218. [10.1006/geno.1994.1366]

Mapping of the Human NMDAR2B Receptor Subunit Gene (GRIN2B) to Chromosome 12p12

P. Finelli;
1994

Abstract

The N-methyl-d-aspartate (NMDA) receptor channel is essential for synaptic transmission and synaptic plasticity underlying memory, learning, and development. Three subunits of the NMDA receptor channel, NMDAR2A, NMDAR2B, and NMDAR2C (NR2A, NR2B, and NR2C), previously identified in mouse by cDNA cloning and expression, share a high level of homology, although their patterns of expression within the brain may differ. In the present work we report the localization of the gene encoding the human NMDAR2B receptor subunit (called GRIN2B for glutamate receptor, ionotropic, N -methyl-d-aspartate 2B) to chromosome 12p12 by in situ hybridization and somatic cell hybrids.
Settore MED/03 - Genetica Medica
lug-1994
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/188979
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