Platelets isolated from patients with hypercholesterolemia are more sensitive in vitro to various aggregating agents, including epinephrine, than those isolated from normocholesterolemic subjects. Increased platelet reactivity is one mechanism that may explain the enhanced risk of thromboembolism in hypercholesterolemia. This study assessed whether platelet hyperreactivity to epinephrine in hypercholesterolemia is associated with higher alpha 2-adrenergic receptor density or affinity for epinephrine.

Platelet alpha 2-adrenergic receptors in hypercholesterolemia: relationship between binding studies and epinephrine-induced platelet aggregation / D. Baldassarre, N. Mores, S. Colli, F. Pazzucconi, C. R. Sirtori, E. Tremoli. - In: CLINICAL PHARMACOLOGY & THERAPEUTICS. - ISSN 0009-9236. - 61:6(1997 Jun), pp. 684-691.

Platelet alpha 2-adrenergic receptors in hypercholesterolemia: relationship between binding studies and epinephrine-induced platelet aggregation

D. Baldassarre
Primo
;
S. Colli;F. Pazzucconi;C. R. Sirtori
Penultimo
;
E. Tremoli
Ultimo
1997

Abstract

Platelets isolated from patients with hypercholesterolemia are more sensitive in vitro to various aggregating agents, including epinephrine, than those isolated from normocholesterolemic subjects. Increased platelet reactivity is one mechanism that may explain the enhanced risk of thromboembolism in hypercholesterolemia. This study assessed whether platelet hyperreactivity to epinephrine in hypercholesterolemia is associated with higher alpha 2-adrenergic receptor density or affinity for epinephrine.
Humans; Lipids; Yohimbine; Aged; Adrenergic alpha-Antagonists; Receptors, Adrenergic, alpha-2; Platelet Aggregation; Adult; Case-Control Studies; Middle Aged; Epinephrine; Hypercholesterolemia; Female; Male
Settore BIO/12 - Biochimica Clinica e Biologia Molecolare Clinica
giu-1997
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/188886
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