Aberrations of the p53 gene (also known as TP53) frequently lead to the synthesis of mutant proteins that accumulate in the nuclei and/or cytoplasm of neoplastic cells. Intracellular p53 protein accumulation may be an unfavorable prognostic parameter in breast, lung, ovarian, gastric, and colorectal cancers. Specific classes of p53 gene mutations, assayed by characteristic subcellular p53 protein accumulation patterns, may be useful prognostic indicators.
Cytoplasmic accumulation of p53 protein: an independent prognostic indicator in colorectal adenocarcinomas / S. Bosari, G. Viale, P. Bossi, M. Maggioni, G. Coggi, J. J. Murray, A. K. Lee. - In: JOURNAL OF THE NATIONAL CANCER INSTITUTE. - ISSN 0027-8874. - 86:9(1994 May 04), pp. 681-687.
Titolo: | Cytoplasmic accumulation of p53 protein: an independent prognostic indicator in colorectal adenocarcinomas |
Autori: | BOSARI, SILVANO (Primo) VIALE, GIUSEPPE (Secondo) |
Parole Chiave: | Tumor Suppressor Protein p53; Neoplasm Staging; Humans; Retrospective Studies; Prognosis; Predictive Value of Tests; Cell Nucleus; DNA, Neoplasm; Cytoplasm; Statistics as Topic; Adenocarcinoma; Ploidies; Immunohistochemistry; Colorectal Neoplasms; Female; Male; Survival Analysis |
Settore Scientifico Disciplinare: | Settore MED/08 - Anatomia Patologica |
Data di pubblicazione: | 4-mag-1994 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1093/jnci/86.9.681 |
Appare nelle tipologie: | 01 - Articolo su periodico |