The association of the hepatitis C virus (HCV) with the cryoglobulinemic syndrome is well known, but its pathogenetic mechanism still remains to be clarified. HCV-RNA has been found in the peripheral blood mononuclear cells (PBMC) of infected subjects. We investigated the presence of the HCV genome in bone marrow cells (BMC), and the distribution of different HCV genotypes in individuals with mixed cryoglobulinemia (MC) and in noncryoglobulinemic controls.
HCV genotypes in bone marrow and peripheral blood mononuclear cells of patients with mixed cryoglobulinemia / G. Zehender, C. de Maddalena, G. Monti, M. Ballare, F. Saccardo, S. Piconi, F. Invernizzi, A. Monteverde, M. Galli. - In: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. - ISSN 0392-856X. - 13 Suppl 13:13(1995), pp. S87-S90.
HCV genotypes in bone marrow and peripheral blood mononuclear cells of patients with mixed cryoglobulinemia
G. ZehenderPrimo
;C. de MaddalenaSecondo
;M. GalliUltimo
1995
Abstract
The association of the hepatitis C virus (HCV) with the cryoglobulinemic syndrome is well known, but its pathogenetic mechanism still remains to be clarified. HCV-RNA has been found in the peripheral blood mononuclear cells (PBMC) of infected subjects. We investigated the presence of the HCV genome in bone marrow cells (BMC), and the distribution of different HCV genotypes in individuals with mixed cryoglobulinemia (MC) and in noncryoglobulinemic controls.
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