The effects of Metformin treatment on platelet responsiveness to aggregating agents was studied in cholesterol-fed rabbits. Three groups of animals were fed, for one month, either a normal (N), or a hypercholesterolemic (HC), or a hypercholesterolemic + 0.5% Metformin diet (HC + Met), Platelets from the HC rabbits required significantly lower collagen and arachidonic acid concentrations to aggregate, as compared to platelets from N rabbits. The platelet response from the HC + Met rabbits was not significantly different from that of normals. The cholesterol/phospholipid ratio in platelets was increased in both dietary groups (HC, HC + Met). The serum thromboxane B2 concentrations did not show any significant difference between the groups. Plasma exchange experiments failed to indicate a specific effect of the plasma environment on platelet behaviour. In view of the inactivity of metformin on the platelet cyclo-oxygenase pathway, the reported results suggest that metformin may act by an as yet unexplored mechanism.
Metformin reduces platelet hypersensitivity in hypercholesterolemic rabbits / E. Tremoli, G. Ghiselli, P. Maderna, S. Colli, C. R. Sirtori. - In: ATHEROSCLEROSIS. - ISSN 0021-9150. - 41:1(1982 Jan), pp. 53-60.
|Titolo:||Metformin reduces platelet hypersensitivity in hypercholesterolemic rabbits|
TREMOLI, ELENA (Primo)
COLLI, SUSANNA (Penultimo)
SIRTORI, CESARE (Ultimo)
|Parole Chiave:||Experimental hypercholesterolemia; Metformin; Platelet hypersensitivity|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||gen-1982|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/0021-9150(82)90069-7|
|Appare nelle tipologie:||01 - Articolo su periodico|