The sensitivity to PGI2 of platelets of 20 selected type IIa hypercholesterolemic patients was studied and compared to that of platelets of 14 normocholesterolemic subjects. Type IIa subjects required higher concentrations of PGI2 to inhibit platelet aggregation elicited by 1 microM ADP, 1 microgram/ml collagen and 1.4 microM epinephrine. Adenylate cyclase activity was also measured in washed platelet membranes from the two groups of subjects. Adenylate cyclase activity, both basal and PGI2-stimulated, was not statistically different in the two groups examined. Therefore changes at the level of PGI2 receptors coupled to adenylate cyclase are not likely to be responsible for the different platelet sensitivity to prostacyclin.

Effects of PGI2 on platelet aggregation and adenylate cyclase activity in human type IIa hypercholesterolemia / S. Colli, M. Lombroso, P. Maderna, E. Tremoli, S. Nicosia. - In: BIOCHEMICAL PHARMACOLOGY. - ISSN 0006-2952. - 32:13(1983 Jul 01), pp. 1989-1993.

Effects of PGI2 on platelet aggregation and adenylate cyclase activity in human type IIa hypercholesterolemia

S. Colli
Primo
;
E. Tremoli
Penultimo
;
S. Nicosia
Ultimo
1983-07-01

Abstract

The sensitivity to PGI2 of platelets of 20 selected type IIa hypercholesterolemic patients was studied and compared to that of platelets of 14 normocholesterolemic subjects. Type IIa subjects required higher concentrations of PGI2 to inhibit platelet aggregation elicited by 1 microM ADP, 1 microgram/ml collagen and 1.4 microM epinephrine. Adenylate cyclase activity was also measured in washed platelet membranes from the two groups of subjects. Adenylate cyclase activity, both basal and PGI2-stimulated, was not statistically different in the two groups examined. Therefore changes at the level of PGI2 receptors coupled to adenylate cyclase are not likely to be responsible for the different platelet sensitivity to prostacyclin.
Platelet Aggregation; Blood Platelets; Enzyme Activation; Humans; Prostaglandins; Hyperlipoproteinemia Type II; Adult; Epoprostenol; Middle Aged; Adenylate Cyclase; Male; Female
Settore BIO/14 - Farmacologia
Settore BIO/10 - Biochimica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/188734
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