A novel and effective chain-extension procedure for obtaining high-molecular-weight PLGA-based bioerodible polymers is described. This procedure consists in a polycondensation reaction between PLGA thermal oligomers of average molecular weight 1000-3000 and bischlorofomates of either simple diols or α,ω-bis-hydroxylated oligomers, such as polyethyleneglycols or bis-hydroxy terminated poly-∈-caprolactones. In the latter case, multiblock copolymers are obtained. By varying the nature and the length of the starting diol, as well as the lactic/glycolic acid molar ratio in the starting PLGA oligomer, products with widely different physicochemical properties can be synthesized. In particular, dissolution times in aqueous media can be tuned within an ample range, from a few days to several months. This provides exceptional opportunities for designing products whose properties are tailored in view of specific applications in the biomedical field.
|Titolo:||A new chain extension reaction on poly(lactic-glycolic acid) (PLGA) thermal oligomers leading to high molecular weight PLGA-based polymeric products|
RANUCCI, ELISABETTA (Secondo)
|Parole Chiave:||Bioerodible polymers; Bischlorofomates; Multiblock copolymers; Poly-∈-caprolac-tone; Polycondensation; Polyethyleneglycol; Polyflactic-glycolic acid|
|Settore Scientifico Disciplinare:||Settore CHIM/04 - Chimica Industriale|
|Data di pubblicazione:||1998|
|Digital Object Identifier (DOI):||10.1002/(SICI)1097-0126(199807)46:3<203::AID-PI975>3.3.CO;2-8|
|Appare nelle tipologie:||01 - Articolo su periodico|