The title compds. I (R = H, OH; R1 = H, (un)substituted C1-4 alkyl), II (Y = C1-5 alkylmercapto, (un)substituted PhS, C1-5 alkylsulfinyl, (un)substituted phenylsulfinyl, etc.), and III (X = Cl, Br), which demonstrate antibiotic activity against gram pos. and neg. microorganisms, fungi, and protozoa, and which are suitable for the treatment of vaginal infections, are prepd. and pharmaceutical formulations contg. them presented. Thus, 7'-(ethylamino)purpuromycin, prepd. in 6 steps from purpuromycin, demonstrated min. inhibitory concn. of 8 μg/mL against Trichomonas vaginalis and 2μg/mL against Gardnerella vaginalus (ATCC 14018).
7'-Aminonaphthazarin antibiotic derivatives / A. Trani, C. Dallanoce, R. Ciabatti.
7'-Aminonaphthazarin antibiotic derivatives
C. DallanoceSecondo
;
1993
Abstract
The title compds. I (R = H, OH; R1 = H, (un)substituted C1-4 alkyl), II (Y = C1-5 alkylmercapto, (un)substituted PhS, C1-5 alkylsulfinyl, (un)substituted phenylsulfinyl, etc.), and III (X = Cl, Br), which demonstrate antibiotic activity against gram pos. and neg. microorganisms, fungi, and protozoa, and which are suitable for the treatment of vaginal infections, are prepd. and pharmaceutical formulations contg. them presented. Thus, 7'-(ethylamino)purpuromycin, prepd. in 6 steps from purpuromycin, demonstrated min. inhibitory concn. of 8 μg/mL against Trichomonas vaginalis and 2μg/mL against Gardnerella vaginalus (ATCC 14018).
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