The title compds. I (R = H, OH; R1 = H, (un)substituted C1-4 alkyl), II (Y = C1-5 alkylmercapto, (un)substituted PhS, C1-5 alkylsulfinyl, (un)substituted phenylsulfinyl, etc.), and III (X = Cl, Br), which demonstrate antibiotic activity against gram pos. and neg. microorganisms, fungi, and protozoa, and which are suitable for the treatment of vaginal infections, are prepd. and pharmaceutical formulations contg. them presented. Thus, 7'-(ethylamino)purpuromycin, prepd. in 6 steps from purpuromycin, demonstrated min. inhibitory concn. of 8 μg/mL against Trichomonas vaginalis and 2μg/mL against Gardnerella vaginalus (ATCC 14018).

7'-Aminonaphthazarin antibiotic derivatives / A. Trani, C. Dallanoce, R. Ciabatti.

7'-Aminonaphthazarin antibiotic derivatives

C. Dallanoce
Secondo
;
1993

Abstract

The title compds. I (R = H, OH; R1 = H, (un)substituted C1-4 alkyl), II (Y = C1-5 alkylmercapto, (un)substituted PhS, C1-5 alkylsulfinyl, (un)substituted phenylsulfinyl, etc.), and III (X = Cl, Br), which demonstrate antibiotic activity against gram pos. and neg. microorganisms, fungi, and protozoa, and which are suitable for the treatment of vaginal infections, are prepd. and pharmaceutical formulations contg. them presented. Thus, 7'-(ethylamino)purpuromycin, prepd. in 6 steps from purpuromycin, demonstrated min. inhibitory concn. of 8 μg/mL against Trichomonas vaginalis and 2μg/mL against Gardnerella vaginalus (ATCC 14018).
Gruppo Lepetit S.p.A.,Italia
WO93/12115
PCT/EP92/02764
Settore CHIM/08 - Chimica Farmaceutica
7'-Aminonaphthazarin antibiotic derivatives / A. Trani, C. Dallanoce, R. Ciabatti.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/188482
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