A synthetic process for obtaining high-molecular-weight block copolymers containing poly(lacticglycolic acid) and poly(ethylene glycol) segments has been established. This process involves the reaction of poly(ethylene glycols) with phosgene, followed by polycondensation of the resulting α,ω-bis (chloroformates) with poly(lactic-glycolic acid) oligomers. The copolymers have been characterized for their molecular weight, solubility properties, water absorption and preliminarily thermal behaviour. All evidence points to the conclusion that the process described is a general one, enabling biodegradable polymers to be obtained tailor-made according to specific requirements.

SYNTHESIS AND PROPERTIES OF NOVEL BLOCK-COPOLYMERS CONTAINING POLY(LACTIC-GLYCOLIC ACID) AND POLY(ETHYLENEGLYCOL) SEGMENTS / F. P., P. M., D. P., E. Ranucci, D. R.. - In: BIOMATERIALS. - ISSN 0142-9612. - 16:18(1995), pp. 1423-1428.

SYNTHESIS AND PROPERTIES OF NOVEL BLOCK-COPOLYMERS CONTAINING POLY(LACTIC-GLYCOLIC ACID) AND POLY(ETHYLENEGLYCOL) SEGMENTS

E. Ranucci
Ultimo
;
1995

Abstract

A synthetic process for obtaining high-molecular-weight block copolymers containing poly(lacticglycolic acid) and poly(ethylene glycol) segments has been established. This process involves the reaction of poly(ethylene glycols) with phosgene, followed by polycondensation of the resulting α,ω-bis (chloroformates) with poly(lactic-glycolic acid) oligomers. The copolymers have been characterized for their molecular weight, solubility properties, water absorption and preliminarily thermal behaviour. All evidence points to the conclusion that the process described is a general one, enabling biodegradable polymers to be obtained tailor-made according to specific requirements.
Biodegradation; block copolymers; poly(ethylene glycol); poly(lactic-glycolic acid)
Settore CHIM/04 - Chimica Industriale
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/188476
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